Huetteroth lab

Huetteroth lab


Our workhorse is the fruit fly Drosophila melanogaster, but we have worked with other critters in the past (Manduca, Tribolium, Aethina, Collembola,…) and intend to stay open-minded in the future!

Utilizing the ever-expanding genetic toolbox for Drosophila we employ a combination of anatomy, behavior, genetics and functional imaging to address our research questions:

1. Feeding regulation and caloric memory formation

We are studying feeding regulation in Drosophila, and the effect of internal states like hunger on locomotion and food intake. We are especially interested in how caloric information is sensed by the organism to influence behavior. How is this information relayed to higher brain circuits and integrated with internal states to influence memory formation? How does it affect sensory perception? How can the pleiotropic role of neuropeptides in signal mediation be disentangled?

2. Voluntary passive movement

Many animals expose themselves to passive movement like swinging, sliding and spinning. Do insects do the same if they have the choice, and if yes - why? We are trying to find answers to these questions to better understand the evolutionary advantage of intentional exafference.


Curriculum vitae


  • Studies of Biology, Philipps-University Marburg, Germany, and University of Edinburgh, UK
  • Diploma in 2002
  • Ph.D. work, Philipps-University Marburg, Germany, in the lab of Prof. J. Schachtner
  • Ph.D. degree (Dr. rer. nat.) 2008
  • Postdoctoral fellow, University of Massachusetts Medical School, MA, USA and University of Oxford, UK in the lab of Prof. Scott Waddell (2009-2014)
  • ZIF Marie-Curie Postdoctoral fellow, Konstanz University, Germany (2014-2017)
  • Independent principal investigator, Leipzig University, Germany (2017- 2021)

Honors and awards

  • 2007 JSPS summer program fellowship, Tokyo, Japan
  • 2009 Marine Biol. Laboratory (MBL) summer course “Neurobiology”, MA, USA
  • 2012 Research fellowship, Wolfson College, University of Oxford, UK
  • 2013 Oxford Martin School Fellow, University of Oxford, UK
  • 2013 Grass fellowship, MBL, Massachusetts, USA
  • 2018 Dujardín prize, ANN, Altleiningen, Germany


Kontakt: Dr. Wolf Huetteroth

letzte Änderung: 08.03.2021

selected Publications

The Panopticon - assessing the effect of starvation on prolonged fly activity and place preference. Mahishi D, Hesse R, Triphan T, Huetteroth W (2021) Front Syst Neurosci (accepted)

Two Parallel Pathways Mediate Olfactory-Driven Backward Locomotion. Israel S, Rozenfeld E, Weber D, Huetteroth W, Parnas M (2020) bioRxiv

Neurogenetics of insect behavior: ethology touching base with the scaffold of life. Huetteroth W, Pauls D (2019) Curr Opin Insect Sci 36:iii-iv

The prandial process in flies. Mahishi D, Huetteroth W (2019) Curr Opin Insect Sci 36:157-166

Neuropeptides in modulation of Drosophila behavior: how to get a grip on their pleiotropic actions. Nässel DR, Pauls D, Huetteroth W (2019) Curr Opin Insect Sci 36:1-8

Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body. Perisse E, Owald D, Barnstedt O, Talbot CB, Huetteroth W, Waddell S (2016) Neuron 90:1086-1099

Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila. Huetteroth W, Perisse E, Lin S, Klappenbach M, Burke C, Waddell S (2015) Curr Biol 25:751-758

Layered reward signaling through dopamine and octopamine in Drosophila. Burke C*, Huetteroth W*, Owald D, Krashes MJ, Perisse E, Das G, Gohl D, Silies M, Certel S, Waddell S (2012) Nature 492:433-437

A pair of inhibitory neurons are a critical part of a neural circuit sustaining labile memory in the Drosophila mushroom body. Pitman JL*, Huetteroth W*, Burke C, Krashes MJ, Lai S-L, Lee T, Waddell S (2011) Curr Biol 21:855-861

3D-reconstructions and virtual 4D visualization to study metamorphic brain development in the sphinx moth Manduca sexta. Huetteroth W*, el Jundi B*, el Jundi S, Schachtner J (2010) Front Syst Neurosci 4:7

Standard three-dimensional glomeruli of the Manduca sexta antennal lobe: a tool to study both developmental and adult neuronal plasticity. Huetteroth W, Schachtner J (2005) Cell Tissue Res 319(3):513-524